Mesothelioma (cancer) cells form long-range connections (TNTs) that mediate intercellular transfer of GFP-expressing virus. from bystander effect cancer Watch Video
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Description: MSTO-211H cells transfected with NV1066 form long-range connections via TNTs, which mediate intercellular transfer of virus-expressed eGFP. Cells were cultured in low serum, hyperglycemic medium for 48 hours.NV1066 HSV was added at MOI of 0.1.Time lapse images were captured every 10 seconds using a Zeiss LSM5 Live microscope.nPublished by Ady et al, Tunneling nanotubes: an alternate route for propagation of the bystander effect following oncolytic viral infection, Molecular Therapy-Oncolytic