New inhibitor prevents lesions and reduces tumour size in basal cell cancer from ptch Watch Video
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Description: A new hedgehog pathway inhibitor demonstrated efficacy in preventing and treating basal cell cancer among patients with basal cell nevus syndrome, a rare inheritable disease. It is known that basal cell nevus syndrome is caused by a mutation in the PTCH gene, which encodes a primary inhibitor of the hedgehog signalling pathway. Using this information, researchers developed the anti-hedgehog signalling pathway drug GDC-0449.nnnnDr Ervine Epstein discusses the extremely positive results of a Phase
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