_using-networks-to-link-genotype-to-phenotype-john-quackenbush.jpg "Using networks to link genotype to phenotype- John Quackenbush from 11 standard biology Video Screenshot Preview")
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⏲ Duration: 38 min 54 sec
✓ Published: 25-Jul-2017
✓ Published: 25-Jul-2017
Description:
The problem with genome-wide association studies (GWAS) is dramatically illustrated in two recent publications. The first analyzed data from 253,288 individuals and found that 697 single nucleotide polymorphisms (SNPs) could explain about 20% of human height variability, but approximately 9,500 SNPs were needed to raise that to 29% (1). The second surveyed 339,224 individuals and identified 97 loci that can account for 2.7% of body mass index (BMI) variation (2). These and other similar results
The problem with genome-wide association studies (GWAS) is dramatically illustrated in two recent publications. The first analyzed data from 253,288 individuals and found that 697 single nucleotide polymorphisms (SNPs) could explain about 20% of human height variability, but approximately 9,500 SNPs were needed to raise that to 29% (1). The second surveyed 339,224 individuals and identified 97 loci that can account for 2.7% of body mass index (BMI) variation (2). These and other similar results
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