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_drone-footage-of-chinese-rocket-launched-a-yaogan-34-satellite.jpg "China’s Long March 4C rocket launched the Yaogan-34 04 satellite from the Jiuquan Satellite Launch Center.<br/>The rocket sheds insulation tiles during launch, a normal occurrence. <br/><br/>Credit: Space.com | footage courtesy: China Central Television (CCTV) | edited by Steve Spaleta")
⏲ 1:19 👁 670K
_this-is-a-tougher-variant-of-the-gorocco.jpg "Its tougher, hits harder and moves are somewhat more unpredictable than the normal ones.<br/><br/>#CerberusGaming , #StarWars , #JediSurvivor , #Gorocco , #fyp")
⏲ 1:37 👁 20K
_sally-phillips-is-proud-to-be-39not-that-normal39.jpg "Sally Phillips is proud to not be \")
⏲ 1:37 👁 310K
_abigail-movie-2024-full-hd-movies.jpg "-Horror - Drama -Abigail 2024 Movies sub English Full Episodes FullMovie<br/>After a group of criminals kidnap the ballerina daughter of a powerful underworld figure, they retreat to an isolated mansion, unaware that they're locked inside with no normal little girl.<br/>Directors<br/>Matt Bettinelli-Olpin Tyler Gillett<br/>")
⏲ 1:24:30 👁 130K
_drake-surfaces-to-watch-adonis-play-soccer-weeks-after-shooting-at-home.jpg "Drake's trying to get back to normal life after a month of craziness on the home front -- which included a shooting -- and nothing screams normal more than a proud soccer dad in a cardigan.")
⏲ 0:49 👁 15K
_what-if-2024-episode-06-124-chinese-drama-with-english-subtitles.jpg "What If (2024)\")
⏲ 52:29 👁 40K
_what-if-2024-episode-07-124-chinese-drama-with-english-subtitles.jpg "What If (2024)\")
⏲ 44:14 👁 15K
_what-if-2024-episode-04-124-chinese-drama-with-english-subtitles.jpg "What If (2024)\")
⏲ 45:53 👁 15K
_what-if-2024-episode-03-124-chinese-drama-with-english-subtitles.jpg "What If (2024)\")
⏲ 41:41 👁 15K
_mission-weekly-124-levels-400-124-normal.jpg "Stick War Legacy<br/><br/>Play the game Stick War, one of the biggest, most fun, challenging and addicting person figure games. Control your troops in formation or play each unit, you have complete control over everyone. Build units, mine gold, learn the ways of Swords, Spears, Archers, Wizards and even Giants. Destroy enemy statues, and take all Territory!<br/><br/>In a world called Inamorta, you are surrounded by discriminatory nations who devote themselves to each country's technology and strive for dominance. Each country has developed its own unique way of defending and attacking. Proud of their unique craft, they became obsessed to the point of cult, turning weapons into religion. Each believes that their way of life is the only way, and is dedicated to teaching their policies to all other nations through what their leaders claim to be divine intervention, or as you will know... war.<br/><br/>The others are known as: \")
⏲ 11:44 👁 15K
_namal-lake-a-historical-oasis-facing-modern-challenges.jpg "Nestled near the village of Rikhi, in the picturesque Namal Valley of the Mianwali District in Punjab, Pakistan, lies Namal Lake, a tranquil body of water that has played a vital role in the region’s history and development. This article delves into the rich history of Namal Lake, its significance, and the pressing challenges it faces today.<br/><br/>Historical Significance: Namal Lake owes its existence to the construction of Namal Dam in 1913 by British engineers. Its creation aimed to address the pressing issues of irrigation and drinking water scarcity in the region. The dam effectively formed a sizable lake, which, with normal rainfall, stands at an elevation of R.L. 1,160, about 20 feet below the crest of the weir. During average seasons, it can hold an impressive 630 million cubic feet of water, with a maximum capacity of 2,100 million cubic feet.<br/><br/>https://www.pakistantraveler.com/namal-lake/")
⏲ 2:41 👁 10K
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.jpg "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
⏲ 1:42 👁 10K
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_drone-footage-of-chinese-rocket-launched-a-yaogan-34-satellite.webp "China’s Long March 4C rocket launched the Yaogan-34 04 satellite from the Jiuquan Satellite Launch Center.<br/>The rocket sheds insulation tiles during launch, a normal occurrence. <br/><br/>Credit: Space.com | footage courtesy: China Central Television (CCTV) | edited by Steve Spaleta")
_this-is-a-tougher-variant-of-the-gorocco.webp "Its tougher, hits harder and moves are somewhat more unpredictable than the normal ones.<br/><br/>#CerberusGaming , #StarWars , #JediSurvivor , #Gorocco , #fyp")
_sally-phillips-is-proud-to-be-39not-that-normal39.webp "Sally Phillips is proud to not be \")
_abigail-movie-2024-full-hd-movies.webp "-Horror - Drama -Abigail 2024 Movies sub English Full Episodes FullMovie<br/>After a group of criminals kidnap the ballerina daughter of a powerful underworld figure, they retreat to an isolated mansion, unaware that they're locked inside with no normal little girl.<br/>Directors<br/>Matt Bettinelli-Olpin Tyler Gillett<br/>")
_drake-surfaces-to-watch-adonis-play-soccer-weeks-after-shooting-at-home.webp "Drake's trying to get back to normal life after a month of craziness on the home front -- which included a shooting -- and nothing screams normal more than a proud soccer dad in a cardigan.")
_what-if-2024-episode-06-124-chinese-drama-with-english-subtitles.webp "What If (2024)\")
_what-if-2024-episode-07-124-chinese-drama-with-english-subtitles.webp "What If (2024)\")
_what-if-2024-episode-04-124-chinese-drama-with-english-subtitles.webp "What If (2024)\")
_what-if-2024-episode-03-124-chinese-drama-with-english-subtitles.webp "What If (2024)\")
_mission-weekly-124-levels-400-124-normal.webp "Stick War Legacy<br/><br/>Play the game Stick War, one of the biggest, most fun, challenging and addicting person figure games. Control your troops in formation or play each unit, you have complete control over everyone. Build units, mine gold, learn the ways of Swords, Spears, Archers, Wizards and even Giants. Destroy enemy statues, and take all Territory!<br/><br/>In a world called Inamorta, you are surrounded by discriminatory nations who devote themselves to each country's technology and strive for dominance. Each country has developed its own unique way of defending and attacking. Proud of their unique craft, they became obsessed to the point of cult, turning weapons into religion. Each believes that their way of life is the only way, and is dedicated to teaching their policies to all other nations through what their leaders claim to be divine intervention, or as you will know... war.<br/><br/>The others are known as: \")
_namal-lake-a-historical-oasis-facing-modern-challenges.webp "Nestled near the village of Rikhi, in the picturesque Namal Valley of the Mianwali District in Punjab, Pakistan, lies Namal Lake, a tranquil body of water that has played a vital role in the region’s history and development. This article delves into the rich history of Namal Lake, its significance, and the pressing challenges it faces today.<br/><br/>Historical Significance: Namal Lake owes its existence to the construction of Namal Dam in 1913 by British engineers. Its creation aimed to address the pressing issues of irrigation and drinking water scarcity in the region. The dam effectively formed a sizable lake, which, with normal rainfall, stands at an elevation of R.L. 1,160, about 20 feet below the crest of the weir. During average seasons, it can hold an impressive 630 million cubic feet of water, with a maximum capacity of 2,100 million cubic feet.<br/><br/>https://www.pakistantraveler.com/namal-lake/")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZv5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
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