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_how-taylor-swift-and-travis-kelce-are-reportedly-doing-now-that-eras-tour-is-on-hiatus-and-football-season-is-over.jpg "Most of the time, Taylor Swift and Travis Kelce are booked and busy. Just take a look at Swift’s list of upcoming projects and the NFL’s schedule, and you’ll see just how true that point is. However, at the moment, the pop star is on a break from her Eras Tour, and after winning the Super Bowl, the Kansas City Chiefs tight end is enjoying the off-season. So, how is their relationship going now that they both have a “Blank Space” in their schedules? Well, a source gave an alleged answer to that question.<br/><br/>Reportedly, this power couple is thriving in their off time. Both are taking a much-deserved break from their work, and according to ET, they’ve been enjoying it together by taking a vacation to the Bahamas and spending a lot of time in Los Angeles.")
⏲ 1:8 👁 30K
_why-english-willow-cricket-bats-are-so-expensive.jpg "India is home to a number of the top cricket-bat manufacturers, including Sareen Sports, SS. But the wood used to make the highest-quality bats needs to be shipped halfway across the globe from England. JS Wright & Sons, an English willow tree supplier that has been in the industry since the 1800s, supplies 75% of the willow for the world's cricket bats. English willow bats are durable, yet lightweight and sell for up to 10 times as much as cheaper, lower-end Kashmir willow bats. Growing these trees and using them to create a perfect bat is a more than 15-year-long process that requires a careful eye and years of experience. The trees need to be regularly inspected and maintained so they grow slowly and produce a clean, tight-grained cleft. But the best trees could be in short supply as the sport spreads into more countries, like the United States.<br/><br/>Editor's Note: At 2:30, the video incorrectly states that an English willow tree is ready to be cut down when it is 60 inches in diameter. It should say 60 inches in circumference.")
⏲ 13:53 👁 365K
_how-taylor-swift-and-travis-kelce-are-reportedly-doing-now-that-eras-tour-is-on-hiatus-and-football-season-is-over.jpg "Most of the time, Taylor Swift and Travis Kelce are booked and busy. Just take a look at Swift’s list of upcoming projects and the NFL’s schedule, and you’ll see just how true that point is. However, at the moment, the pop star is on a break from her Eras Tour, and after winning the Super Bowl, the Kansas City Chiefs tight end is enjoying the off-season. So, how is their relationship going now that they both have a “Blank Space” in their schedules? Well, a source gave an alleged answer to that question.<br/><br/>Reportedly, this power couple is thriving in their off time. Both are taking a much-deserved break from their work, and according to ET, they’ve been enjoying it together by taking a vacation to the Bahamas and spending a lot of time in Los Angeles.")
⏲ 1:8 👁 25K
_funniest-cats-and-dogs-124-funny-animals.jpg "ChatGPT<br/><br/>I need description about funny cats animals <br/>ChatGPT<br/>Funny cats are a source of endless amusement and joy for many pet owners and animal lovers. These playful and curious creatures have a knack for getting into amusing situations and displaying quirky behaviors that can lighten anyone's mood. Here are some characteristics and behaviors that make cats particularly funny:<br/><br/>Playful Antics: Cats love to play, often chasing after toys, laser pointers, or even their own tails. Their sudden bursts of energy and acrobatic leaps can be both impressive and hilarious.<br/><br/>Unexpected Reactions: Cats are known for their dramatic responses to new or unexpected stimuli, such as cucumbers, loud noises, or unfamiliar objects. These reactions can range from exaggerated jumps to intense curiosity, making for great entertainment.<br/><br/>Funny Sleeping Positions: Cats can fall asleep in the most unusual and contorted positions, often looking incredibly uncomfortable yet completely content. Finding a cat snoozing upside down or with limbs stretched out in all directions can be both puzzling and amusing.<br/><br/>Facial Expressions: Cats have a wide range of facial expressions that can be quite expressive. From a look of disdain to wide-eyed surprise, their faces often seem to convey human-like emotions, adding to their comedic charm.<br/><br/>Curiosity: Cats' inquisitive nature leads them to explore and investigate everything around them. This curiosity can result in them getting stuck in tight spaces, knocking things over, or peeking out from unexpected places, much to the amusement of onlookers.<br/><br/>Interactions with Other Pets: When cats interact with other animals, such as dogs or other cats, their behaviors can be quite entertaining. Whether they're play-fighting, cuddling, or simply ignoring each other, these interactions often provide plenty of laughs.<br/><br/>Mischief Makers: Cats have a tendency to get into trouble, whether it's knocking objects off tables, unraveling toilet paper rolls, or sneaking into places they shouldn't be. Their mischievous antics are often funny and endearing.<br/><br/>These behaviors and traits make cats a beloved subject for funny videos, memes, and social media posts, bringing joy and laughter to millions around the world")
⏲ 4:25 👁 15K
_the-new-porsche-macan-turbo-in-racing-green-driving-video.jpg "It’s all down to this line, a mere stroke on paper. And yet it marks a a new beginning. The coupé-like roofline of the Macan and the striking rear—with its shape so typical of Porsche—evoke the tight, unmistakable flyline of the 911. But this time, it’s not just a reminder of the Porsche icon. Rather, the shape, including the rear spoiler, is a groundbreaking innovation in the all-electric SUV segment. “The active aerodynamic elements all contribute significantly to the range,” says aerodynamics specialist Thomas Wiegand. “We have a rear spoiler that raises automatically, active cooling flaps at the front air intakes, and flexible covers on the underbody.” Located in the same building as the Style Porsche design department, the Weissach wind tunnel gives form and shape to the streamlining of the newly developed Macan. It’s the first Porsche based on the Premium Platform Electric (PPE) created in collaboration with Audi. This platform not only benefits from development synergies, but is also highly flexible, enabling Porsche to implement its own technical and brand-specific objectives. Full electrification of the popular model line is an important milestone on the path to ensuring that more than 80 percent of the new cars are fully electrified in 2030—depending on the demand of customers and the development of electromobility in the respective regions of the world.")
⏲ 3:2 👁 40K
_10-high-cholesterol-symptoms-you-must-know-essential-health-alert-shorts-viral-top-health.jpg "10 High Cholesterol Symptoms You Must Know: Essential Health Alert<br/><br/>High cholesterol is a silent condition that can lead to serious health complications if left unchecked. In this video, we highlight 10 crucial symptoms related to high cholesterol that you need to be aware of. From chest pain and shortness of breath to fatty deposits and high blood pressure, recognizing these signs can be a life-saver. Stay informed and proactive about your health. Don't forget to like, subscribe, and hit the bell icon for more health tips and information!\")
⏲ 0:38 👁 10K
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.jpg "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
⏲ 1:42 👁 10K
_why-english-willow-cricket-bats-are-so-expensive.jpg "India is home to a number of the top cricket-bat manufacturers, including Sareen Sports, SS. But the wood used to make the highest-quality bats needs to be shipped halfway across the globe from England. JS Wright & Sons, an English willow tree supplier that has been in the industry since the 1800s, supplies 75% of the willow for the world's cricket bats. English willow bats are durable, yet lightweight and sell for up to 10 times as much as cheaper, lower-end Kashmir willow bats. Growing these trees and using them to create a perfect bat is a more than 15-year-long process that requires a careful eye and years of experience. The trees need to be regularly inspected and maintained so they grow slowly and produce a clean, tight-grained cleft. But the best trees could be in short supply as the sport spreads into more countries, like the United States.<br/><br/>Editor's Note: At 2:30, the video incorrectly states that an English willow tree is ready to be cut down when it is 60 inches in diameter. It should say 60 inches in circumference.")
⏲ 13:53 👁 305K
_india-vs-ireland-t20-world-match-92-india-won-this-match-by-8-wickets.jpg "India played against Ireland in a T20 International match, which India won. Here is a detailed description of the match:<br/><br/>**Match Summary:**<br/>- **Teams:** India vs. Ireland<br/>- **Format:** T20 International<br/>- **Venue:** The match took place at a neutral venue, providing both teams an equal playing field.<br/>- **Result:** India won the match.<br/><br/>**Key Highlights:**<br/>- **Batting Performance:** The Indian batting lineup showcased an impressive performance. Key batsmen, such as the top-order and middle-order players, contributed significantly to the team's total score. The openers provided a solid start, and the middle order capitalized on it, leading to a competitive total.<br/>- **Bowling Performance:** India's bowling attack was equally effective. The bowlers managed to restrict the Irish batsmen with tight lines and variations, making it difficult for them to chase the target. Key bowlers took crucial wickets at regular intervals, ensuring Ireland couldn't build substantial partnerships.<br/>- **Fielding:** India's fielding was sharp, with several crucial catches and run-outs that turned the game in their favor. The team's athleticism in the field added pressure on the Irish batsmen.<br/><br/>**Match Impact:**<br/>- This win bolstered India's standing in the series/tournament, showcasing their dominance in the shorter format of the game.<br/>- The performance highlighted India's depth in both batting and bowling departments, providing positive signs for future matches and tournaments.<br/><br/>Overall, India's comprehensive victory over Ireland in the T20 match demonstrated their prowess and strategic gameplay, contributing to their reputation as a strong contender in international cricket.")
⏲ 11:19 👁 95K
_ex-nfler-brandon-pettigrew-arrested-after-punching-breaking-store39s-glass-door-124-tmz-sports.jpg "Former Detroit Lions tight end Brandon Pettigrew spent part of his Sunday morning in jail ... after he punched and broke a glass door during a spat with authorities inside a Texas convenience store.")
⏲ 5:0 👁 25K
_unforeseen-chaos-mom39s-love-faces-the-messy-reality-of-parenthood.jpg "Her baby wasn't feeling well. He was suffering from a fever and was nestled comfortably on her chest. She gently rocked back and forth, humming a soothing lullaby to ease the baby's discomfort. <br/><br/>The room was quiet, filled only with the soft sounds of their breathing. She felt a mixture of concern and tenderness, hoping her little one would soon feel better.<br/><br/>Suddenly, without warning, the baby coughed and vomited all over her. She gasped, her eyes widening in surprise, as she felt the warm mess spread across her shirt. For a moment, she was unable to react. <br/>Location: Melbourne, Australia<br/>WooGlobe Ref : WGA723256<br/>For licensing and to use this video, please email licensing@wooglobe.com")
⏲ 0:9 👁 10K
_cdc-data-flirt-covid-19-strains-increasing-in-the-u-s.jpg "CDC Data: FLiRT COVID-19 Strains Increasing in the U.S.<br/>KP.2 and KP.3 were estimated to be responsible for a combined 2 in 5 infections over the past two weeks, according to CDC estimates.<br/>Certain FLiRT COVID-19 variants are on the rise in the U.S., according to the latest data from the Centers for Disease Control and Prevention.<br/><br/>But so far, data released by health officials suggests there’s little reason to be alarmed.<br/><br/>.2, which is the most prevalent variant circulating in the U.S., was responsible for more than 28% of new infections in the last two weeks, according to CDC estimates released Friday. That’s up from about 20% the two weeks prior.<br/>KP.3 – another FLiRT variant and descendent of JN.1 – was responsible for nearly 13% of new coronavirus cases, which is a jump from close to 8% in the previous estimate.<br/><br/>Taken together, KP.2 and KP.3 were estimated to be responsible for more than 2 in 5 new infections in recent weeks. The FLiRT COVID-19 strains don’t yet appear to produce any new or unique symptoms. Typical COVID-19 symptoms include fever, cough, sore throat and runny nose.<br/><br/>COVID-19 vaccines are expected to work on the strains, but vaccine uptake for the latest updated shot was not what many hoped it would be, with fewer than 23% of adults rolling up their sleeves for it, according to CDC data.<br/><br/>The group of COVID-19 strains gained the nickname FLiRT from the technical terms used for their mutations. The World Health Organization this month deemed both KP.2 and KP.3 “variants under monitoring,” which is a term “used to signal to public health authorities that a SARS-CoV-2 variant may require prioritized attention and monitoring.”<br/><br/>“The main objective of this category is to investigate if this variant (and others closely related to it) may pose an additional threat to global public health as compared to other circulating variants,” according to WHO.<br/><br/>KP.2 and KP.3 are also increasing globally, according to a WHO report.<br/><br/>The strains don’t appear to be driving an increase in COVID-19 health metrics, like deaths or hospitalizations, in the U.S. so far. COVID-19 hospitalizations recently hit their lowest level since the pandemic began. And wastewater viral activity, which can help track both symptomatic and asymptomatic infections, is currently considered “minimal” on the national level, according to the CDC.<br/><br/>“KP.2 is the main variant in the U.S. but isn’t causing an increase in COVID-19 infections or more severe illness than other variants,” according to the CDC.<br/><br/>CDC vaccine advisers will meet in June to talk about the next round of COVID-19 shots and what strain or strains it should target.")
⏲ 2:52 👁 10K
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_how-taylor-swift-and-travis-kelce-are-reportedly-doing-now-that-eras-tour-is-on-hiatus-and-football-season-is-over.webp "Most of the time, Taylor Swift and Travis Kelce are booked and busy. Just take a look at Swift’s list of upcoming projects and the NFL’s schedule, and you’ll see just how true that point is. However, at the moment, the pop star is on a break from her Eras Tour, and after winning the Super Bowl, the Kansas City Chiefs tight end is enjoying the off-season. So, how is their relationship going now that they both have a “Blank Space” in their schedules? Well, a source gave an alleged answer to that question.<br/><br/>Reportedly, this power couple is thriving in their off time. Both are taking a much-deserved break from their work, and according to ET, they’ve been enjoying it together by taking a vacation to the Bahamas and spending a lot of time in Los Angeles.")
_why-english-willow-cricket-bats-are-so-expensive.webp "India is home to a number of the top cricket-bat manufacturers, including Sareen Sports, SS. But the wood used to make the highest-quality bats needs to be shipped halfway across the globe from England. JS Wright & Sons, an English willow tree supplier that has been in the industry since the 1800s, supplies 75% of the willow for the world's cricket bats. English willow bats are durable, yet lightweight and sell for up to 10 times as much as cheaper, lower-end Kashmir willow bats. Growing these trees and using them to create a perfect bat is a more than 15-year-long process that requires a careful eye and years of experience. The trees need to be regularly inspected and maintained so they grow slowly and produce a clean, tight-grained cleft. But the best trees could be in short supply as the sport spreads into more countries, like the United States.<br/><br/>Editor's Note: At 2:30, the video incorrectly states that an English willow tree is ready to be cut down when it is 60 inches in diameter. It should say 60 inches in circumference.")
_how-taylor-swift-and-travis-kelce-are-reportedly-doing-now-that-eras-tour-is-on-hiatus-and-football-season-is-over.webp "Most of the time, Taylor Swift and Travis Kelce are booked and busy. Just take a look at Swift’s list of upcoming projects and the NFL’s schedule, and you’ll see just how true that point is. However, at the moment, the pop star is on a break from her Eras Tour, and after winning the Super Bowl, the Kansas City Chiefs tight end is enjoying the off-season. So, how is their relationship going now that they both have a “Blank Space” in their schedules? Well, a source gave an alleged answer to that question.<br/><br/>Reportedly, this power couple is thriving in their off time. Both are taking a much-deserved break from their work, and according to ET, they’ve been enjoying it together by taking a vacation to the Bahamas and spending a lot of time in Los Angeles.")
_funniest-cats-and-dogs-124-funny-animals.webp "ChatGPT<br/><br/>I need description about funny cats animals <br/>ChatGPT<br/>Funny cats are a source of endless amusement and joy for many pet owners and animal lovers. These playful and curious creatures have a knack for getting into amusing situations and displaying quirky behaviors that can lighten anyone's mood. Here are some characteristics and behaviors that make cats particularly funny:<br/><br/>Playful Antics: Cats love to play, often chasing after toys, laser pointers, or even their own tails. Their sudden bursts of energy and acrobatic leaps can be both impressive and hilarious.<br/><br/>Unexpected Reactions: Cats are known for their dramatic responses to new or unexpected stimuli, such as cucumbers, loud noises, or unfamiliar objects. These reactions can range from exaggerated jumps to intense curiosity, making for great entertainment.<br/><br/>Funny Sleeping Positions: Cats can fall asleep in the most unusual and contorted positions, often looking incredibly uncomfortable yet completely content. Finding a cat snoozing upside down or with limbs stretched out in all directions can be both puzzling and amusing.<br/><br/>Facial Expressions: Cats have a wide range of facial expressions that can be quite expressive. From a look of disdain to wide-eyed surprise, their faces often seem to convey human-like emotions, adding to their comedic charm.<br/><br/>Curiosity: Cats' inquisitive nature leads them to explore and investigate everything around them. This curiosity can result in them getting stuck in tight spaces, knocking things over, or peeking out from unexpected places, much to the amusement of onlookers.<br/><br/>Interactions with Other Pets: When cats interact with other animals, such as dogs or other cats, their behaviors can be quite entertaining. Whether they're play-fighting, cuddling, or simply ignoring each other, these interactions often provide plenty of laughs.<br/><br/>Mischief Makers: Cats have a tendency to get into trouble, whether it's knocking objects off tables, unraveling toilet paper rolls, or sneaking into places they shouldn't be. Their mischievous antics are often funny and endearing.<br/><br/>These behaviors and traits make cats a beloved subject for funny videos, memes, and social media posts, bringing joy and laughter to millions around the world")
_the-new-porsche-macan-turbo-in-racing-green-driving-video.webp "It’s all down to this line, a mere stroke on paper. And yet it marks a a new beginning. The coupé-like roofline of the Macan and the striking rear—with its shape so typical of Porsche—evoke the tight, unmistakable flyline of the 911. But this time, it’s not just a reminder of the Porsche icon. Rather, the shape, including the rear spoiler, is a groundbreaking innovation in the all-electric SUV segment. “The active aerodynamic elements all contribute significantly to the range,” says aerodynamics specialist Thomas Wiegand. “We have a rear spoiler that raises automatically, active cooling flaps at the front air intakes, and flexible covers on the underbody.” Located in the same building as the Style Porsche design department, the Weissach wind tunnel gives form and shape to the streamlining of the newly developed Macan. It’s the first Porsche based on the Premium Platform Electric (PPE) created in collaboration with Audi. This platform not only benefits from development synergies, but is also highly flexible, enabling Porsche to implement its own technical and brand-specific objectives. Full electrification of the popular model line is an important milestone on the path to ensuring that more than 80 percent of the new cars are fully electrified in 2030—depending on the demand of customers and the development of electromobility in the respective regions of the world.")
_10-high-cholesterol-symptoms-you-must-know-essential-health-alert-shorts-viral-top-health.webp "10 High Cholesterol Symptoms You Must Know: Essential Health Alert<br/><br/>High cholesterol is a silent condition that can lead to serious health complications if left unchecked. In this video, we highlight 10 crucial symptoms related to high cholesterol that you need to be aware of. From chest pain and shortness of breath to fatty deposits and high blood pressure, recognizing these signs can be a life-saver. Stay informed and proactive about your health. Don't forget to like, subscribe, and hit the bell icon for more health tips and information!\")
![MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>](https://cdn4.hifimov.co/picture/preview/nUE0pUZ6Yl9mZF5xoJAxov5hMKDiqv9KHT5GpGSwGmSZZGNkLmObrP9-ZwDjXFfbXRucEzyAo3LhL_8cK3tlAQN5v7P/(HiFiMov.co)_how-your-body-metabolizes-medications.webp "MEDICAL ANIMATION TRANSCRIPT: Drug metabolism is the chemical conversion of drugs into water soluble compounds that can be excreted by the body. Drug metabolism mainly takes place in the liver, while excretion mainly takes place in the kidneys. Following drug administration, drugs must pass through tightly packed cells, crossing cell membranes to reach their sites of action. Usually drugs are lipophilic or fat soluble compounds, and cell membranes are composed of phospholipids, so drugs are able to cross them. However, for excretion by the kidneys, it's necessary to convert drugs to water soluble or hydrophilic compounds. Drugs are usually administered orally or parenterally. Parenteral drugs bypass the digestive tract. Parental routes include injection, transdermal patches, lotions, inhalants, and suppositories. If injected, the drugs reach general circulation quickly and have an immediate effect. If taken orally, drugs must pass through the cells of the gastrointestinal tract. Drugs cross through cells of the GI tract and travel to the liver via the hepatic portal vein. The liver has a chance to metabolize some of the drug before it goes into general circulation, this is called the first pass effect. In the liver, drugs enter hepatic cells where a series of enzymes in smooth endoplasmic reticulum metabolize them. Drugs move through the phospholipid membrane of endoplasmic reticulum. Hepatic microsomal enzymes such as p450 convert drugs from lipophilic to hydrophilic compounds. Repeated use of certain drugs increases the amount of metabolic enzymes and increases drug metabolism. This is called enzyme induction. Conversely, certain drugs compete to bind to metabolic enzymes thereby decreasing drug metabolism. This is called enzyme inhibition. Once metabolized, these hydrophilic metabolites leave the cell ready for excretion by the kidney. A drug's duration and intensity of effect are largely determined by metabolic rate. Increased metabolic rate will decrease drug duration and intensity by facilitating excretion. Decreased metabolic rate increases drug duration and intensity. A few of the factors affecting metabolic rate are the first pass effect, liver disease such as cirrhosis, neonates in the elderly have decreased liver function, compromised blood flow to the liver will lower metabolic rate, variation in amount and type of hepatic enzymes, poor diet and nutrition can affect normal liver function, and higher circulating drug levels due to dosage or patient's weight take longer to metabolize. ♪ [music] ♪<br/>")
_why-english-willow-cricket-bats-are-so-expensive.webp "India is home to a number of the top cricket-bat manufacturers, including Sareen Sports, SS. But the wood used to make the highest-quality bats needs to be shipped halfway across the globe from England. JS Wright & Sons, an English willow tree supplier that has been in the industry since the 1800s, supplies 75% of the willow for the world's cricket bats. English willow bats are durable, yet lightweight and sell for up to 10 times as much as cheaper, lower-end Kashmir willow bats. Growing these trees and using them to create a perfect bat is a more than 15-year-long process that requires a careful eye and years of experience. The trees need to be regularly inspected and maintained so they grow slowly and produce a clean, tight-grained cleft. But the best trees could be in short supply as the sport spreads into more countries, like the United States.<br/><br/>Editor's Note: At 2:30, the video incorrectly states that an English willow tree is ready to be cut down when it is 60 inches in diameter. It should say 60 inches in circumference.")
_india-vs-ireland-t20-world-match-92-india-won-this-match-by-8-wickets.webp "India played against Ireland in a T20 International match, which India won. Here is a detailed description of the match:<br/><br/>**Match Summary:**<br/>- **Teams:** India vs. Ireland<br/>- **Format:** T20 International<br/>- **Venue:** The match took place at a neutral venue, providing both teams an equal playing field.<br/>- **Result:** India won the match.<br/><br/>**Key Highlights:**<br/>- **Batting Performance:** The Indian batting lineup showcased an impressive performance. Key batsmen, such as the top-order and middle-order players, contributed significantly to the team's total score. The openers provided a solid start, and the middle order capitalized on it, leading to a competitive total.<br/>- **Bowling Performance:** India's bowling attack was equally effective. The bowlers managed to restrict the Irish batsmen with tight lines and variations, making it difficult for them to chase the target. Key bowlers took crucial wickets at regular intervals, ensuring Ireland couldn't build substantial partnerships.<br/>- **Fielding:** India's fielding was sharp, with several crucial catches and run-outs that turned the game in their favor. The team's athleticism in the field added pressure on the Irish batsmen.<br/><br/>**Match Impact:**<br/>- This win bolstered India's standing in the series/tournament, showcasing their dominance in the shorter format of the game.<br/>- The performance highlighted India's depth in both batting and bowling departments, providing positive signs for future matches and tournaments.<br/><br/>Overall, India's comprehensive victory over Ireland in the T20 match demonstrated their prowess and strategic gameplay, contributing to their reputation as a strong contender in international cricket.")
_ex-nfler-brandon-pettigrew-arrested-after-punching-breaking-store39s-glass-door-124-tmz-sports.webp "Former Detroit Lions tight end Brandon Pettigrew spent part of his Sunday morning in jail ... after he punched and broke a glass door during a spat with authorities inside a Texas convenience store.")
_unforeseen-chaos-mom39s-love-faces-the-messy-reality-of-parenthood.webp "Her baby wasn't feeling well. He was suffering from a fever and was nestled comfortably on her chest. She gently rocked back and forth, humming a soothing lullaby to ease the baby's discomfort. <br/><br/>The room was quiet, filled only with the soft sounds of their breathing. She felt a mixture of concern and tenderness, hoping her little one would soon feel better.<br/><br/>Suddenly, without warning, the baby coughed and vomited all over her. She gasped, her eyes widening in surprise, as she felt the warm mess spread across her shirt. For a moment, she was unable to react. <br/>Location: Melbourne, Australia<br/>WooGlobe Ref : WGA723256<br/>For licensing and to use this video, please email licensing@wooglobe.com")
_cdc-data-flirt-covid-19-strains-increasing-in-the-u-s.webp "CDC Data: FLiRT COVID-19 Strains Increasing in the U.S.<br/>KP.2 and KP.3 were estimated to be responsible for a combined 2 in 5 infections over the past two weeks, according to CDC estimates.<br/>Certain FLiRT COVID-19 variants are on the rise in the U.S., according to the latest data from the Centers for Disease Control and Prevention.<br/><br/>But so far, data released by health officials suggests there’s little reason to be alarmed.<br/><br/>.2, which is the most prevalent variant circulating in the U.S., was responsible for more than 28% of new infections in the last two weeks, according to CDC estimates released Friday. That’s up from about 20% the two weeks prior.<br/>KP.3 – another FLiRT variant and descendent of JN.1 – was responsible for nearly 13% of new coronavirus cases, which is a jump from close to 8% in the previous estimate.<br/><br/>Taken together, KP.2 and KP.3 were estimated to be responsible for more than 2 in 5 new infections in recent weeks. The FLiRT COVID-19 strains don’t yet appear to produce any new or unique symptoms. Typical COVID-19 symptoms include fever, cough, sore throat and runny nose.<br/><br/>COVID-19 vaccines are expected to work on the strains, but vaccine uptake for the latest updated shot was not what many hoped it would be, with fewer than 23% of adults rolling up their sleeves for it, according to CDC data.<br/><br/>The group of COVID-19 strains gained the nickname FLiRT from the technical terms used for their mutations. The World Health Organization this month deemed both KP.2 and KP.3 “variants under monitoring,” which is a term “used to signal to public health authorities that a SARS-CoV-2 variant may require prioritized attention and monitoring.”<br/><br/>“The main objective of this category is to investigate if this variant (and others closely related to it) may pose an additional threat to global public health as compared to other circulating variants,” according to WHO.<br/><br/>KP.2 and KP.3 are also increasing globally, according to a WHO report.<br/><br/>The strains don’t appear to be driving an increase in COVID-19 health metrics, like deaths or hospitalizations, in the U.S. so far. COVID-19 hospitalizations recently hit their lowest level since the pandemic began. And wastewater viral activity, which can help track both symptomatic and asymptomatic infections, is currently considered “minimal” on the national level, according to the CDC.<br/><br/>“KP.2 is the main variant in the U.S. but isn’t causing an increase in COVID-19 infections or more severe illness than other variants,” according to the CDC.<br/><br/>CDC vaccine advisers will meet in June to talk about the next round of COVID-19 shots and what strain or strains it should target.")
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